The EPIC-Norfolk Study
Functional health status, chronic medical conditions and disorders of mood.
The British journal of psychiatry : the journal of mental science 2003 ; 183: 299-303.
Surtees PG, Wainwright NW, Khaw KT, and Day NE
DOI : 10.1192/bjp.183.4.299
PubMed ID : 14519607
PMCID :
Abstract
Understanding of the impact of depressive and anxiety disorders on functional health status in the context of chronic medical illness has been gained almost exclusively from the study of patient populations.
To compare the impact of major depressive and generalised anxiety disorder with that of chronic medical conditions on functional health in a UK resident population.
The functional health of 20,921 study participants was assessed using the Medical Outcomes Study Short Form 36 questionnaire. Depressive and anxiety disorder episode histories and chronic medical conditions were assessed using independent self-completed questionnaires.
The degree of physical functional impairment associated with mood disorders was of equivalent magnitude to that associated with the presence of chronic medical conditions or with being some 12 years older.
Depressive and anxiety disorders have a profound impact on functional health that is independent of chronic medical illness. Chronic anxiety is associated with physical health limitations in excess of those associated with chronic depression or any of the physical health conditions considered, except for stroke.