The EPIC-Norfolk Study
Plasma phospholipid long-chain n-3 polyunsaturated fatty acids and body weight change.
Obesity facts 2011 ; 4: 312-8.
Jakobsen MU, Dethlefsen C, Due KM, Slimani N, Chajès V, May AM, Sørensen TI, Halkjær J, Tjønneland A, Clavel-Chapelon F, Boutron-Ruault MC, Fagherazzi G, Teucher B, Kaaks R, Boeing H, Schütze M, Trichopoulou A, Zylis D, Makrygiannis G, Palli D, Mattiello A, Tagliabue G, van der A DL, Bueno-de-Mesquita HB, Rodriguez L, Travier N, Molina-Montes E, Huerta JM, Barricarte A, Amiano P, Manjer J, Wirfält E, Johansson I, Hallmans G, Khaw KT, Wareham NJ, Crowe F, Romieu I, Riboli E, Peeters PH, and Overvad K
DOI : 10.1159/000330710
PubMed ID : 21921655
PMCID : PMC6444826
Abstract
We investigated the association between the proportion of long-chain n-3 polyunsaturated fatty acids (PUFA) in plasma phospholipids from blood samples drawn at enrollment and subsequent change in body weight. Sex, age, and BMI were considered as potential effect modifiers.
A total of 1,998 women and men participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) were followed for a median of 4.9 years. The associations between the proportion of plasma phospholipid long-chain n-3 PUFA and change in weight were investigated using mixed-effect linear regression.
The proportion of long-chain n-3 PUFA was not associated with change in weight. Among all participants, the 1-year weight change was -0.7 g per 1% point higher long-chain n-3 PUFA level (95% confidence interval: -20.7 to 19.3). The results when stratified by sex, age, or BMI groups were not systematically different.
The results of this study suggest that the proportion of long-chain n-3 PUFA in plasma phospholipids is not associated with subsequent change in body weight within the range of exposure in the general population.